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Adverse reaction to Tasinga & Spyrycel

Hi everyone, I was diagnosed June 2013 and new to this site..... I was put on Tasinga and was just getting used to it when Doc said it was causing liver damage so he put me on Sprycel. I took 1 tablet on Friday nite and was sick all day Saturday ! Called Doc and he said to stop taking it. So I have gone 2 days with no medication, going to see Doc on Monday (tomorrow ) .... I am assuming Gleevec is now my only choice.

I wanted to ask if anyone has had a similar experience ? I am a little concerned that I will have adverse reaction to this as well!

Is anyone on Gleevec ? What side effects are common?

Thanks in advance ......

I am not sure what drugs are available to you where you are but as well as Glivec there is also Bosutinib. I had adverse reactions on both Tasigna and Sprycel although mine was pleural effusion with Sprycel. What dose were you on? It may be better to try you on a lower dose rather than change the medication again?

K

I understand that Sprycel can be taken with or without food. You do not say whether you had eaten or not before you took the drug, but it might make a difference to your reaction.
If this is not relevant to how your reacted, then I agree with Karen that your doctor should try a reduced dose rather than switch therapy so soon. Many take dasatinib (Sprycel) with success and without this kind of reaction.

Welcome to this forum,

Sandy

Hi K , thanks for your reply , I am on 100mg.
Saw Doc today and he said he might try reduced dosage, however due to my liver damage he is giving me a week off any medication to see if it gets beta.

Hi Sandy,
Thanks for your reply, I did not have food with my Sprycel , I saw your post and mentioned this to my Doc and he said after I have a week off my medication he is going to reduce my dose and suggested I try it with food. He thinks my reaction could be due to my damaged liver ( a result of the Tasinga) and hopes a week off any meds will help. Of course I am concerned having a week off medication could negatively impact my CML but I guess I have to trust the Doc!

Thank you very much for replying !!!!

Fiona

Hi Fiona, I like you are new to this site (today) I have joined kind of on behalf of my husband who was diagnosed with CML in January this year. He is taking part in the Spirit2 trials for Dasatanib... he takes 100mg once a day and from day one has it with his evening meal, we are not big eaters but we do have a proper evening meal, he also takes it with lots of water. In general thsat seems to have kept the sickness at bay.... Altho if he is woken up during the night (apart from going to the toilet) then he does feel very sick... but that for him seems to be working at the moment. I do hope you get sorted and can stay on one type of medication to get you stable. regards Melanie

Hi I was diagnosed in 2009 , the only things I have had is swollen eye lids in the mornings , and a bit of cramps and also eye bleeds which are the most irritating .On eve of making a big decision , about to stop medication all together ,a it apprehensive , but nothing ventured nothing gained,being treated at Wolverhampton new cross, going to be monitored every four weeks.I am going to register for Oxford meeting ,anyway why not try to come along,anyway all the best
Tony.

Hi Melanie, thanks for reply, I think when I go back on the Doc will start me with 50mg, and I will def take with food! It's just the nilotinib (Tasinga) used to be with no food so I thought I would be consistent ! How is your husband going ? Has he had to have time off work? Fortunately , I am a stay at home mum and don't need to take time off, but have had to ask my husband to take time off to help me! My kids are only 4 & 6 so sometimes I get tired and need some help! Seeing Doc again on Monday so hopefully my liver is beta , starting to get abit worried!! Cheers, Fiona