Thank you all for inputs and sharing the information.
Your responses gave us ( me & my family) a huge relief and assurance that things are under control.
@cmljax & @AlastairC
1. We always get tests done from the same lab to reduce the noise.
2. I will try to find out if lab has changed the sensitivity of the tests.
@David: Thanks for the re-assurance however I must admit my knowledge is quite limited and thus I can't get my head around the calculation you've mentioned. I will be glad if you can provide me pointers to go through to comprehend same?
May be the Note section in the report could shed some light as to how this lab computes the %.
Note
1. Sensitivity of the assay is 0.01% when copies of ABL detected is 100,000.
2. Limit of detection is 10 copies of BCR-ABL fusion gene transripts per PCR
3. This is an in-house developed assay designed as per EAC (Europe against Cancer) protocol.
4. This test detects Major(M) gene rearrangements namely- e13a2 & e14a2 and Minor(m) gene arragement e1a2. This test
does not detect micro gene arrangement e19a2.
5. Test conducted on Whole blood/Bone Marrow.
6. This test gives % of BCR-ABL fusion gene detected with respect to the ABL transcript presennt as well
as the International scale value to harmonize the result
@Scuba: I must admit I had tears in my eyes when i read "Your mother will NEVER die from CML.." prayers, medication, care and affection have kept us going.
Thanks again to all of you, can't express how much your responses helped us.
/Karan