I consulted with Claude.
How does dasatinib affect my blood numbers?
08:35Claude responded: Looking at your data, here's how dasatinib is likely influencing your blood results: Looking at your data, here's how dasatinib is likely influencing your blood results:
Haemoglobin / Haematocrit — consistently low
Your Hb has ranged from 114–133 g/L, against a male reference of 135–180, and haematocrit has similarly been below the reference range. Dasatinib commonly causes anaemia, and this pattern is consistent throughout your records.
IgG — persistently below range
Your IgG has run at 6.27–6.43 g/L against a reference of 7.0–16.0. Dasatinib can suppress immunoglobulin production, leaving you with a degree of immune vulnerability.
Lymphocytes — variable and sometimes low
You've seen lymphocytes as low as 0.90 and 1.26 ×10⁹/L. Dasatinib is known to alter lymphocyte populations — it expands certain NK/T-cell subsets (which may contribute to its anti-leukaemia effect) while simultaneously reducing overall lymphocyte counts.
Ferritin — low-normal and declining
Your ferritin dropped from 74 to 28 ng/mL. Dasatinib doesn't directly cause iron deficiency, but anaemia of chronic disease from CML treatment can affect iron metabolism. Worth watching.
Potassium — persistently at or just above the upper limit
Readings of 4.7–5.2 mmol/L are notable, as both your losartan and empagliflozin also raise potassium. Dasatinib itself isn't a major cause, but the combination is worth monitoring by your team.
What's reassuringly stable despite dasatinib:
Your platelets, neutrophils, and white cell counts are all comfortably within range — a good sign that your bone marrow is tolerating the reduced 50mg dose well. Your BCR-ABL trajectory is also excellent: from 100% at diagnosis in 2018 down to 0.003% in February 2026, which is deep molecular response territory.
The dose reduction from 100mg to 50mg in December 2025 was likely wise — your haemoglobin and other markers have been more stable in recent months compared to the dip seen mid-2025 (Hb 114 in June 2025).
It would be worth discussing the low IgG and ferritin trends explicitly with your haematologist at your next review, if you haven't already.