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Low WBC, 300mg v 400mg +Neulasta

Hi
Once again I find myself with low WBC and a low neutraphil count, so I have a week off from Gleevac while my counts recover. I have an appointment on Friday with my specialist. What I'd like to know is what the general view out there is on 300mg V 400mg Gleevac + neulasta.

Anyone's comments, ideas, suggestions or experience would be very welcome, especially if you're on 300mg. I know Dr Drucker's advocates will say 400 + neulasta but will someone please tell me 300 can do the trick!
In anticipation
Vanessa

dxd June 2006
PCRU Sept 2006

In the lab, 350mg was the minimum effective dose......which translates to the 400mg dose (as 350mg is not made).

You did have a very quick response to Gleevec, becoming PCRU in only a few months....so the drug is very effective for you. I do know someone who is a Dr. Druker patient and was having a very bad time on 400mg (requiring red cell transfusions). Dr. Druker was able to get some blood serum levels tested for her (not much access to this) and has her on 300mg and may even alternate with 200mg daily. Yes there are some people who have done well on 300mg....and there are some who have relapsed over time on 300mg. But there is not a good way to determine this except trial and error! If you decided with your doctor to drop your dose to 300mg, you could monior your PCR closely and see if you go positive on a test.

Nancy C.

Thank you Nancy
That's helpful.
Vanessa