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Considerations for Successful Treatment-free Remission
Stuart L. Goldberg, Michael Savona, Michael J. Mauro
Conclusions and Future Directions
Approximately 40% to 60% of those patients with CML-CP, who achieve sustained (≥ 2 years) deep molecular response (DMR) with TKI therapy, can achieve TFR. Molecular relapses typically occurred within 6 months, and patients quickly regained their prior depth of MR upon retreatment with the same TKI. As such, many TFR trials require monthly RQ-PCR monitoring for the first 6 to 12 months, with a gradual reduction in frequency thereafter. Clinical progression of CML related to participation in a TFR study has been observed only once, although fear of progression could limit patient participation in trials.