Capsule Summary CCO Independent Conference Coverage of the American Society of Hematology 2008 Annual Meeting*
Cytogenetic Response to Dasatinib Predictive for Progression-Free Survival in Imatinib-Resistant/Intolerant CML Patients
Posting Date: December 12, 2008
Analysis[1] of pooled data from 2 phase II clinical trials: SRC-ABL Tyrosine Kinase Inhibition Activity Research Trial (START)–C and START-R
Summary of Key Conclusions
Cytogenetic responses rapidly attained with dasatinib 70 mg twice daily in imatinib-resistant/intolerant patients with chronic-phase chronic myeloid leukemia (CML)
89% of all complete cytogenetic responses achieved within first 12 months of treatment
47% of responses achieved within first 3 months of treatment
Cytogenetic responses highly durable with dasatinib therapy
91% of complete cytogenetic responses maintained during 24 months of follow-up
Achieving both major cytogenetic response and complete cytogenetic response at 12 months highly predictive for PFS
....read more
Capsule Summary CCO Independent Conference Coverage of the American Society of Hematology 2008 Annual Meeting*
Cytogenetic Response to Dasatinib Predictive for Progression-Free Survival in Imatinib-Resistant/Intolerant CML Patients
Posting Date: December 12, 2008
Analysis[1] of pooled data from 2 phase II clinical trials: SRC-ABL Tyrosine Kinase Inhibition Activity Research Trial (START)–C and START-R
Summary of Key Conclusions
Cytogenetic responses rapidly attained with dasatinib 70 mg twice daily in imatinib-resistant/intolerant patients with chronic-phase chronic myeloid leukemia (CML)
89% of all complete cytogenetic responses achieved within first 12 months of treatment
47% of responses achieved within first 3 months of treatment
Cytogenetic responses highly durable with dasatinib therapy
91% of complete cytogenetic responses maintained during 24 months of follow-up
Achieving both major cytogenetic response and complete cytogenetic response at 12 months highly predictive for PFS
....read more