This has been a long journey on Dasatinib trying to find a dose that will be efffective without overly depressing the other blood counts. Up until now I thought I only had the Philadelphia chromosome. This is so disappointing as I had finally reached a PCR of 0.03.
I started Dasatinib 50mg on 31 Oct '17. At first we stopped the drug or reduced it in several cycles as and when the Neutrophil count dropped. Neupogen was introduced in 22 Aug '18. Revolade was introduced 8 Sep '20 to support the low platelet count. Any time I came off the Dasatinib the PCR increased.
Under the microscope there are blast cells in the blood sample (less than 20 % I think).
I've had two tests for mutations in previous years which showed nothing.
I have another blood test Wednesday 30 Nov '22. Her concern is not to let the blood counts multiply out of control. We'll both know more then.
My consultant is concerned that I am moving into the accelerated phase of CML; that there are other clones. I only had the biopsy done last week and we're waiting on the results. It's difficult to get hold of Ponatinib here so that's why it has been ordered. It will take more than a week to arrive.
Thanks fo your advice.