I found this a really interesting video presentation about the Phase 1 Dose-Escalation Study of PF-04449913, an Oral Hedgehog Inhibitor, in Patients With Select Hematologic Malignancies---- including CML.
ClinicalTrials.gov NCT00953758
The Hh (hedgehog) pathway and SMO inhibitors seems to successfully target LCS (leukaemic stem cells)
http://thesciencenetwork.org/programs/industry-academia-translational-on...