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Nilotinib side effects

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Hi,

I was diagnosed as CML on Feb 2016 and was started on Nilotinib, 300mg once per day. 3 weeks after that, my liver enzymes level was 5 times above normal. I was asked to stop Nilotinib for 2.5 weeks and the liver enzymes level went gradually back to normal. Since then, I started Nilotinib again, but at 150mg once every day. It has been a month since restarting the Nilotinib and I shall see the doctor in 3 weeks time. I want to know if anyone has the same experience?

Thanks,

Emily

Hi Emily,

it is not unusual for clinicians to manage the effects of TKIs by dose reductions in the first few months of therapy, especially in the case of raised liver enzymes. I am sure your body will adjust to nilotinib over the next few weeks and you will be able to resume the full dose. 

Best wishes,

sandy

Hi Sandy,

Thanks so much for your information and encouragement!

Emily