I reduced my Sprycel dose to 20 mg a week ago. Actually 25 the first few days as I was splitting 50 mg pills till the new prescription arrived. It really feels like this is going to work for me as far as side effects. I woke up happy the first morning. I'd been attributing my depression to my low thyroid and frustration with the persistent side effects. But then I went off Sprycel for a few days when I was having chest pain and some strange heart beats and I was immediately happy again. I repeated this a few weeks later and got the same results. Of all my side effects I was most worried that I'd not have that return to happiness with the reduced dose, but there it was.
I got a baseline PCR/ABL before the reduction: RESULT: BCR-ABL1 (p210): 0.0243% IS (MR 3.61) Next test late April. Let's hope this dose works to keep the CML in remission as do not want to give it up.
Maria