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Flu like symptoms on Sprycel/Dasatinib

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Hi all,

I started my CML treatment on Jan 13th with 100mg Desatinib. I posted previously asking about side effects and now that I’ve been on it for a few weeks they’ve definitely kicked in. 
 

For the past week I’ve felt like I have the flu, it’s miserable. I have pressure on my chest and up my throat as if I have a sore/swollen throat but I don’t. My eye sockets ache like someone has punched me and I have had a cracking headache every day. I wake up feeling terrible like I’m unwell but I don’t have any actual flu symptoms like coughing or sneezing. I also wake up daily with nausea that seems to last until around 2pm.

 

I take my pill at 7:30pm and then I feel like crap basically from 2am (I’ve been waking up most nights unwell) to 2pm. I have a 12 hour period in between where it subsides but then it starts up again. I have my first/next doctors appointment since starting on Feb 11 so i‘ll obviously check in there but I was wondering if anyone else had this type of response? I am hoping it’s just cause I am getting used to it and waiting to wake up feeling better again. Fingers crossed! I am also on 300mg allopurinol which may be adding to it. 
 

Thanks in advance!

Hi, when you come off the Allopurinol you should feel a bit better ,I did anyway caused terrible diahorea.When I started on Dasatinib I refused to start on 100 mg ,I had heard big burly 6 foot men being floored with side effects so as a 5 foot 3 lady I said it will be well too toxic for me .My Doc didn't agree but I showed her recent research saying lower dose works so she gave in .Please don't continue with your awful side effects insist on a lower dose of 50 mg it works for me .Hope it works for you too .I keep saying don't be bullied it's your body and you have to be strong .You can always go up a bit if it doesn't work but you have to try .GOOD LUCK ,Denise .

I started on 100mg and i felt terrible too. I had to finally insist that we drop the dose to 50mg. My Dr didn't want to but she finally agreed to 70. Then 50 and side effects are much better and no difference with my counts. Tell your Dr you need to try 50mg. 100mg knocked me on my butt!! 

 

Tom