You are here

Question for Scuba Re:D3

As many of your know @Scuba is one of the best posters on this forum.

Rather than cluttering up his thread on fasting+tki, I wanted to ask a question which may benefit others as well as myself.

Here is my question: Will you please provide the link for the study which explains the 70ng/ml cut off point for keeping the blast cells to "die off" ?

I have searched high and low and cannot come across any paper which details this.

Scuba, in one of your posts, you recommend D3 with the following:

"Increase vitamin D3 supplementation so your blood D level is at least 70 ng/ml. At this dose (+/-), CML blast cells differentiate into daughter cells and die off. CML blast cells are the real problem in CML and when reduced to zero or near zero, gives time to experiment with dose overall."

First of all, I want to go on record as saying that I agree. I have been taking D3+K2 (7000IUs:200mcg) per day. My lab from a few weeks ago showed D3 levels at 66ng. Since that result, I have increased my D3 to 8000IUs and divided the dose to 4000IUs w/meal and another 4000IUs w/meal (currently 2 meals per day on IF).

As a matter of fact, the D3+K2 protocol - in addition to other adjuvant methods - has, in my opinion, brought my numbers to a more manageable level. And my blast count is <0.1% (as of Feb/23 lab).

Again, I want to reiterate that I completely agree with your thesis and my goal is to keep my D3 above 70ng. I'm just curious where I can locate the study.

Thank you in advance.

 

EDIT: February 13, 2023

I miscalculated the amount I had been taking. The post gives the correct amount in IUs.

Regulation of Leukemic Cell Differentiation through the Vitamin D Receptor at the Levels of Intracellular Signal Transduction, Gene Transcription, and Protein Trafficking and Stability

Vitamin D Control of Hematopoietic Cell Differentiation and Leukemia

(Nice chart on blood levels)

I am trying to find the video presentation which details 70 ng/ml as a "sweet spot" level for anti-cancer (and leukemia). The link I have is broken.

 

I'll add those to my library of research.

If you ever get that link working re:70ng level, please post. Or even the title of the lecture/research/vid etc. might me enough for me to find a way.

Thanks!

Hi There,

 

Thanks for this information it is really interesting.

What about vitamin C? Can, does it have any similar or positive effects if consumed in high doses? 

cheers

The video described the DINOMIT model of vitamin's role in cancer. The link (old) I had doesn't work any more as the site went private.

Here is a link to one of the videos discussing the DINOMIT model,

https://www.youtube.com/watch?v=SwE3M4Ka_OE

Note the charts Dr. Garland shows detailing vitamin D blood levels and cancer risk. Near the end of the video he summarizes.

Between 60 ng/ml - 100 ng/ml is the zone to target for maximum benefit. 70 is the sweet spot. It is hard to maintain "one" number (i.e. "70"). The goal is to elevate your vitamin D level to be above 60 most of the  time. When my blood level is above 70, I cut back, when it is below 70 I increase supplement dose. Over the years I have learned, that for me, 5,000 IU's daily in summer and 8,000 IU's per day in winter keeps me around 70 ng/l and above 60 ng/ml. During the dark of winter (cloudy skies for days on end), I take as much as 10,000 IU's per day most days of the week. I never exceed 10,000 IU"s per day.

An important point to note from the video: Cancer incidence (breast cancer) can be greatly reduced by as much as 50%, just by getting vitamin D blood levels near 50 ng/ml. (24:40 mark in the video) and up to 85% at 60 ng/ml. Above 70 ng/ml increased benefit is not observed - and the difference between 60 - 70 ng/ml in terms of increased benefit is marginal.

When I was diagnosed with CML, my vitamin D blood level was 17 ng/ml.

 

Thank you!

EDIT: On my phone, laptop, and tv the audio is not working. But your synopsis is very helpful and there are other videos on youtube with him discussing the subject.

And to Scuba's comment about his low levels at diagnosis, when I was diagnosed, I had been working 5+ years on the third shift, sleeping during the day, and overall getting very little sun. The paltry d levels I got from a multivitamin and food did not come anywhere close to the amounts I'm currently taking to stay above 60ng.

Will definitely take the advice and keep that sweet spot between 60-70.

You might find the information about D3 levels provided on the grassrootshealth.net site helpful. Sandy

Will look into it. Thanks very much!

As stated in an earlier post, I could not make the audio in that particular video work.

So I decided to watch several of Dr Garland's lectures on youtube.

I found one which I believe many will benefit from. Although he does not cover cml, he does cover other cancers. And the information from that can and should be extrapolated to us with cml. Quite alarming it only has 360 views at the time of this post because the information in the lecture so critically important.

I encourage others to watch the entire video. Pay close attention to around the 48 minute mark. In that Dr Garland clearly states that all cancer patients should be repleted to equal or greater than 65ng/ml.

Other highlights include the DINOMIT model (brilliant, imo) as well as why those in the North Eastern part of the U.S. have greater cancer numbers as opposed to the North West - even though both areas are at similar distance above the equator.

https://www.youtube.com/watch?v=Vts5_9yTeFU

Interestingly - Dr. Garland passed away from esophageal cancer (2010). He probably was taking vitamin D supplements and measuring his vitamin D blood level prior to his diagnosis given his research in vitamin D. It did not prevent his cancer which ultimately killed him (60 years old).

Vitamin D, by itself, is not a "cure" or will prevent cancer outright. It is a risk reducer - and in combination with lifestyle adjustments to reduce chronic inflammation can be a significant cancer risk reducer. Think in terms of what you eat that could be causing chronic inflammation. Reducing inflammation in the body (which includes losing weight) will go a long way to helping vitamin D do its job.

Mods, if this post is offensive, please remove and send me an email of reprimand.

To Scuba's point, I 100% agree. There really is no one single magic bullet in the prevention of or remission of cancer.

I could not help but notice the late Dr Garland did not appear healthy in all his videos. He was carrying excess adipose tissue. Perhaps, his dedication to vitamin D gave him the false belief that he was allowed to be less proactive in other aspects of health?

Since my dx, I've met many doctors and nurses who simply do not appear healthy. I suspect that they believe they are somehow immune to serious illness due to their training and profession.

The tragic fact that Dr Garland passed from cancer should not dissuade us from his message on D. I have incorporated the importance of the vitamin. However, I continue to research for several hours every morning, exercise, meditate, intermittent fast, and eat a mostly plant based diet.

And most importantly, I remind myself constantly that I do not know what I do not know. An open mind and proactively seeking blind spots is critically important.