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Glossary beginning with T
The commercial name for nilotinib.
The condition of having abnormally low numbers of platelets.
The condition of having abnormally high numbers of platelets.
Tyrosine Kinase Inhibitor (TKI), a molecular targeted therapy designed to block specific proteins that cause leukaemic cells to divide. Imatinib was the first generation in this class of oral therapy; dasatinib, nilotinib, bosutinib and ponatinib are second generation TKIs now used as 1st, 2nd, 3rd and 4th line therapy.
An event that occurs when part of one chromosome breaks off and attaches to a different chromosome. In 1973, Janet D. Rowley at the University of Chicago described the mechanism by which the Philadelphia chromosome arises as a reciprocal translocation between chromosomes 9 and 22.
- Tyrosine kinases
proteins that play a key role in cell signalling processes.