You are here

PCR up

Hi all

I haven't posted for ages been really busy with life and work and stuff.

Just had a reality call though. My PCR has jumped from 0.103 in Oct to 0.533. Looks like they will up my Glivec to start with.

I feel a bit shaken by it all right now.

Hope everyone is doing Ok

Marian

Hi Marian,
I am not sure if you should panic just yet. the rise in your pcr is not that much and may not be significant. you should also wait until you get another result to compare as it may well be that the sample was not a 'good' one.
there are other factors which affect the end result or ratio (which is the % number you end up with)..........
one is the number of normal genes (abl) in the sample (sometimes called the housekeeping gene) the other is the sample size.
do ask you doctor to explain this to you, it really helps when interpreting whether a rise is significant or not.
remember you need to compare at least another 2 more ratios-- or normal (abl) genes to abnormal (bcr/abl) genes-- before you make any decisions about changing you dose.

best wishes,
Sandy ;o)

Thanks Sandy

I really appreciate the reassurance. I do however know that King's want to increase my dose as I haven't got down to a 0.0?? in two years. Perhaps they'll just opt for 600 instead - at least that will be easier to handle.

I have requested a second PCR to be done - soon if possible. My next one is scheduled for beginning of April which is a full on BMB.

Thanks again

Marian

Hi Marian,

Could you send me you email address?

Zavie

zmiller@sympatico.ca

Zavie Miller (age 68)
Ottawa, Canada, dxd AUG/99
INF OCT/99 to FEB/00, CHF
Gleevec since MAR/27/01 (400 mg)
CCR SEP/01. #102 in Zero Club
2.8 log reduction Sep/05
3.0 log reduction Jan/06
> 4 log reduction Nov/06
zmiller@sympatico.ca

YAHOOO!!! YIPPEEE!!!
Number 1145 in the Zero Club
Zavie

Reaching CCR gets you into the Zero Club

Zavie Miller (age 69)
67 Shoreham Avenue
Ottawa, Canada, K2G 3X3
dxd AUG/99
INF OCT/99 to FEB/00, CHF
No meds FEB/00 to JAN/01
Gleevec since MAR/27/01 (400 mg)
CCR SEP/01. #102 in Zero Club
2.8 log reduction Sep/05
3.0 log reduction Jan/06
2.9 log reduction Feb/07
3.2 log reduction Jun/07
3.6 log reduction Sep/07
e-mail: zmiller@sympatico.ca
Tel: 613-726-1117
Fax: 309-296-0807
Cell: 613-202-0204
Yahoo ID: zaviem