I came across this interesting paper that I thought I would share with the group. It was written by an oncologist, and describes a number of case studies of people who were prescribed either imatinib or dasatinib (although they didn't have CML). The common theme is that all patients suffered some level of depression, which tended to get better when they stopped taking the drug.
Although strictly speaking this is not "proof" that TKIs cause depression, I thought it was an interesting insight into the possibility that it might cause it, or at least be correlated in some way.
If nothing else I hope it gives some comfort to any of you who might be feeling this way - you are not alone. And you aren't making it up. It's a very real issue.
Wishing you all much happiness and health.
Bhiru