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Rising PCR & Bosutinib

Hi all, just to let you know whats happening. I have now had three rising PCRS, having gone from virtually undetectable to 1.6 in the last four weeks. I was refused the pace trial as I was too well! But now this is happening. Having been told to stop Bosutinib due to elevated liver function results, I have now been told to go back on it straight away but at the same reduced dose. The correct dose should be 500mg but I only managed 100mg. When the drug was increased to 200mg my liver didnt like it. I am now concerned that such a low dose wont control the rising BCR ABL. Following a call frm the hopsital on Friday they have asked me to go in for another PCR on Monday.
And there was me looking forward to a restfull holiday the follwowing weekend! I know I shall be on the phone chasing results rather than soaking up some sunshine.
Any advise would be welcome.
Thanks to all.

Hi Ali... you liver is obviously complaining loud and clear! The only thing I can suggest is that you consider taking a liver supporting supplement- many are available in good chemists etc- but Health Aid to a good one which contains Amino Acids, Dandelion and Milk Thistle...it is called Livercare.
Or if you have not done so already you could just try Milk Thistle.

Best Sandy
I hope you can relax enough to enjoy your holiday!

Hi Ali - so sorry to hear you're having on-going problems. Is there a chance they would reconsider you for the PACE trial if your results are rising? It must be a real worry. Yes maybe the milk thistle will help support your liver so you can tolerate the drugs. Hope you do manange to still have a good holiday and you get some clarity soon.
best wishes
Joanna