''One common question is what to do with a patient in CCyR but not in MMR or still PCR-positive. Central to this question is what the goal of therapy is. We consider CCyR the gold standard for a good response. The reason is that achieving CCyR is associated with improved survival.1'' ....
''These considerations guide our approach to the patient who has achieved CCyR but not MMR, or the patient who has lost MMR but remains in CCyR. In these instances, we do not recommend any change in therapy.''
Extract of How I treat newly diagnosed chronic phase CML
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