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NGS in CML - New Standard Diagnostic Procedure?

Please see the following page from iCMLf for full details:

Associate Professor Susan Branford, Centre for Cancer Biology Adelaide, Australia

  • CML is a genetically uniform disease: BCR-ABL1
  • Catalogue of somatic mutations in cancer: COSMIC
  • Sanger sequencing is impractical for broad discovery
  • Association of mutated cancer genes and transformation
  • New therapies for BC based on mutation profile
  • Other genes not listed in the cancer gene census?
  • Multiple genomic events may impact outcome