Articles

An investigation into the use of app technology in patients with CML.

Posted on Tuesday, November 5, 2019 - 9:30pm

An investigation into the use of app technology in patients with CML.

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Cessation of nilotinib in patients with CML who have kept deep molecular responses for 2yrs

Posted on Thursday, October 3, 2019 - 12:50pm

Patients who maintained MR4.5 at 24 months of consolidation therapy proceeded to discontinuation of nilotinib.

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Combining Asciminib with Ponatinib Suppresses Emergence Highly Resistant BCR-ABL1 Mutants

Posted on Thursday, October 3, 2019 - 12:42pm

We demonstrate that combining asciminib with ATP site TKIs enhances target inhibition and suppression of resistant outgrowth in Ph+ clinical isolates and cell lines.

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Long‐term follow‐up of lower dose dasatinib (50 mg daily) as frontline therapy in newly diagnosed chronic CML

Posted on Thursday, October 3, 2019 - 12:06pm

Dasatinib, a potent Bcr‐Abl tyrosine kinase inhibitor, is approved for the treatment of chronic‐phase chronic myeloid leukemia (CML‐CP) in the frontline and salvage settings.

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CML: the concepts of resistance and persistence and the relationship with BCR-ABL1

Posted on Thursday, October 3, 2019 - 11:55am

Chronic myeloid leukaemia is driven by a hybrid gene, BCR-ABL1, that codes for a leukemogenic tyrosine kinase (TK) protein of 210 KDa (p210BCR-ABL1).

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Cortes Highlights Second-Generation TKIs for Frontline Therapy in CML

Posted on Friday, August 9, 2019 - 10:59am

Jorge Cortes sees the future of CML care in earlier treatments.

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Video Recordings: UK Chronic Myeloid Leukaemia Patient Day 2019

Posted on Monday, July 15, 2019 - 4:46pm

Chronic Myeloid Leukaemia Patient Day Saturday, 21st September 2019, Leeds Agenda 9.30 – 10.00 Registration CML and its Treatment

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CML Horizons 2019 Presentations and Video streams are available now!

Posted on Saturday, July 6, 2019 - 11:14am

Videos and PDF copies of presentations from the CML Advocates conference, 2019, are now available and can be found by following the link below:

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King's College London - Patient Group (July 24th)

Posted on Saturday, June 29, 2019 - 9:21pm

CML Patient Group at King's College on 24th July 2019. Details below.

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De-Escalation of TKI Therapy Before Complete Treatment Discontinuation in Patients With CML

Posted on Wednesday, June 26, 2019 - 10:42am

BACKGROUND: All studies of treatment-free remission (TFR) in patients with chronic myeloid leukaemia have discontinued tyrosine kinase inhibitor (TKI) treatment abruptly and have focussed on patients...

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CML Horizons Conference Report: Lisbon Portugal May 17th - 19th 2019

Posted on Tuesday, May 28, 2019 - 12:26pm

CML Horizons Conference Lisbon PortugalMay 17th - 19th 2019Nigel Deekes, as the CML Support Group’s conference delegate, describes highlights from this year’s conference.

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