Rocky Mountain Gal sorry to hear about your wild ride. Your symptoms sound severe. Basically early on a TKI should reduce your BCR-ABL to a much safer level quick within a few months but surely on a steady downward path. Maybe Sprycel is not for you. Have they suggested another TKI like imatinib or nilotinib? High out of whack CBC counts in the beginning are typical but definitely need to watch for sure.