Submitted by davidpfitz on Thu, 12/02/2015 - 00:47.
0.24 to 0.3 is a very small increase. Even then, it depends hugely on the number of control genes and the quality of the blood sample. It's totally within margins for error.
I've had a few plateaus - and been worried like you - but then the next one dropped down.
I think that until you have something like three rises in a row there should be no real cause for concern. Much easier said than done, I know.
David.
Submitted by ashu1103 on Wed, 11/02/2015 - 16:01.
hi sandy & ginger,
i received my 12 month pcr 0.30. which was 0.24. at 9 month . confused to what to do.
not able to understand why is it stable or increasing.
I have put this post again in a new thread as the other one is getting a little long.
Ashu- David is right, your pcr 9 and 12 month pcr results are virtually the same.
On the molecular level small changes like this are not significant. Again, as David has already pointed out, you should not take one pcr result as a cause for concern (although naturally any change can cause worry)..... as there are many variables involved before a lab can generate a pcr result that is a good reflection of the actual level of disease present.
These are very low numbers and the difference between .030 and .024 is not significant.
Losing a zero...i.e say your 12 m result had shown a rise from 0.024 to 0.10 .....would be more significant- but again you would need to see an upward trend from more than one test (preferably 3) before you would say your disease levels were not stable.
To answer your question... these 2 results show stable disease.
Sandy
Hi Ashu,
Have a look at this thread. I started it when I was worried my PCR wasn't coming down. 9 months after diagnosis I was at 0.5% and the next month it was 1.1%. 3 months after that it was just around 0.15%. Ups and downs aren't uncommon.
I'm now in MMR at around 0.05%.
http://cmlsupport.org.uk/node/8131
David.
HI SANDY,
GOT MY 15 MONTH PCR 0.056 , WHICH IS COMPARATIVELY BETTER THAN MY 12 MONTH PCR WHICH WAS .32 .FEELING RELAXED ENOUGH. TOMORROW IS MY FIRST WEDDING ANNIVERSARY ,FEELING GOOD. COULD YOU PLEASE HELP ME OUT TO INTERPRET THE RESULT.
REGARDS
ashu
Hi Ashu,
your result shows another log reduction than the previous one so..... you should really celebrate this drop in Bcr/Abl percentage. The result is very good and shows you are responding to therapy. Depending on whether the lab that generated your result is tied to the IS 0.056% is less than MR3 (0.1%) and getting very close to MR4 - which is 0.01%. So no matter how you look at it this is good news.
Congratulations for tomorrows anniversary,
Sandy
