Fathering while taking bosutinib

Hi Max,
over the years there have been lots of discussions about this subject. We know that there is a risk for women being treated with TKIs and the advice is for them not to get pregnant whilst on therapy and/or find another way to control their disease whilst they try to/or are pregnant (a lot of women have successfully produced healthy children by using leukapheresis or some form of treatment with an interferon).

The general feeting is, that for men taking TKIs the risks that their sperm would be a cause of foetal abnormality are the same as that for the 'normal' non-treated male population.

Here is a link to one of the recent discussion on this page about this subject.
http://www.cmlsupport.org.uk/node/8859

I hope this is helpful... but you should always have this kind of conversation with your doctor. With that in mind, you might want to read this interesting article on the subject:
Tyrosine Kinase Inhibitors and Pregnancy
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010610/

A snip from the summary:
"These reports suggest that in a male patient taking Imatinib or Nilotinib, no particular risks of fertility; conception or pregnancy have been evidenced. Caution should be used when patient is taking Dasatinib, due to the very few data available. No reports are available for patients taking Bosutinib or Ponatinib. For those patients, the possibility to cryopreserve sperm before starting therapy should be discussed."