OK! Just took my first 100MG Sprycel Pill today

Best of luck Chuckster. Hope the Sprycel zaps your CML fast and hard.

My husband probably drinks closer to 4 litres daily ( I know , lots of loo stops) . He drinks it at room temperature otherwise he ends up freezing. He does generally feel much colder as well so be prepared to pile on the layers. 

Louise 

Thanks!

Omeprazole with dasatinib is not a good idea, even when taken far apart in the day. Dasatinib needs the acid in your stomach to break it down properly, the very thing which omeprazole neutralises over the whole day.

If possible, manage reflux with gaviscon / gastrocote or similar but don't taken them within 2 hours of each other. 

I used to have terrible reflux, and here's my PCR results before and after getting rid of omeprazole. 

• Aug  13: 0.489%
• Sept 13: 1.04%
• Nov 13: 0.131%
• Nov 13: 0.284%
• Jan 14: 0.369%
• At this point (March 14), omeprazole was withdrawn
• Apr 14: 0.131%
• Aug 14: 0.06%
• And then continually and steadily down to MR 4.5.

David.

Nowadays, I take my Sprycel in the AM typically between 5 AM to 7 AM. - I'm an early riser.  I take 500 mg of Vitamin C with the Sprycel as Sprycel needs an acidic stomach to work at its best..  I have been able to slowly reduce my need for Omeprazole to an OTC pill of 20 mg only needed perhaps 3 times per month. I'm currently on 60 mg of Sprycel and my BCR ABL is .004

When I was taking Sprycel at night, I missed too many doses due to being tired and forgetting.

Your CML doctor absolutely needs to sign off on this before you take it. Acid reducers such as omeprazole will suppress the amount of dasatinib made available to your body. That might be acceptable if your PCR is sufficiently low, but that's a call for your CML doctor.

You can of course also try to manage your reflux through diet changes, weight loss (depending on your weight), and there are even surgical options available to fix the problem. I went down the surgical route to eliminate my reflux.

David.

I take lansoprazole at 8 AM and dasatinib 100 mg at about 2 PM. I have discussed this with my consultant and she is unconcerned about taking these medications together. Pharmacists to whom I have spoken advise a separation of at least two hours. 

I have been taking my synthroid at 6 am. Sprycel 50 mg  at 7 am.  Then I take omeprazole at 5 pm.Before dinner 

I am trying to find better timing.    My counts were. BCR of .0126. And MR of 3.9.  
thank you for your response the more information I can get really helps me feel better and less anxious.

I too am a bread freek I cannot stop eating it.

When I was taking Sprycel at bedtime, I would occasionally fall asleep and miss a dosage of Sprycel.  Missing a dosage of Synthroid is not nearly as large of an error as missing a dosage of Sprycel.  I had my thyroid completely removed as I was "suspicious" of thyroid cancer and I take 200 mcg daily as I don't produce any naturally.

But I take my Sprycel and Synthroid together when I first wake up and then wait 20 to 30 minutes before I eat.  I have not been told to take them at different times and I don't believe that they interact with one another.  I would however wait 4 hours before taking Omeprazole as it reduces the benefits of Sprycel.  Sprycel has a very short half live so I believe that 4 hours is enough of a separation.  The stomach becomes used to Omeprazole.  If you want to reduce your dependence on Omeprazole, you need to titrate your dosage down as opposed to stopping cold turkey.

Best regards!

When I was first diagnosed and about 10 days later I started taking Sprycel at 100 mg I was naturally nervous as hell.  To hear that one has cancer understandably freaks one out but my Doctor said that if you are going to get a cancer, this is the one to get.

About 6 weeks out, I started getting some acute muscle pain in my upper legs.  However, my cancer level plummeted and perhaps at my 6 month appointment, I got my Dr to reduce my dosage to 80 mg and later to 70.  I am presently at 60 mg.  I don't know anything about you but I am now 70 and my present PCR level is .011. I was diagnosed Dec 14, 2016 almost 6 years ago.The first few months might be tough but once you get the right dosage all will be well.  From my viewpoint the medicine is so new that they really don't know what the correct dose should be

You will die - but not from this! and your life expectancy will not have any significant change!  I think this is a private message - send me your email address and I am glad to write you directly.

Some believe that the starting dose of Sprycel should be 50 mg not 100 but you need to work with your Doctor.  

Hang in there!

Thanks for your response

my email is paulafiscella2000@yahoo.com

My dr is saying that I need to wait 12 hours in between omeprazole and sprycel.  Have you still had good level in the way you are taking your drugs

My last BCR was .005  before omeprazole so I am concerned.   I am 73 and holding in there    That was when I was taking synthroid in am with sorycel 

maybe I should leave it at that and take omeprazole before dinner   At least 10 hr after sprycel  thoughts

i was trying to take omeprazole in am and sprycel at night but kept messing up timing

good luck on COVID vaccine    Sorry you are havie a very sick relative   My prayers are with you

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Best wishes,

Sandy

Hello. I hope this is real but my test came back today BCR ABL NON DETECTED

especially since I am also on omeprazole