You are here

HIGH thyroid TSH levels after being on sprycel for 2 years

Categories:

Dear mates,

i have been on dasatanib 100mg daily for 2 years now. i started gaining weight from past one year . every 3 months i am doing thyroid test .

though T3 , T4 level are under normal range TSH keeps increasing for every three months test i undergo. 5.98 before 3 months, 7.91microIU/mL now.

everytime i ask my doctor if i want to take medicines for TSH he is making me wait for next 3 more months.

i am worried as i am gaining weight and loosing all my hair day by day. can someone comment on this.

 

regards,

jilu

Dasatinib impact on thyroid function is well known

https://www.ncbi.nlm.nih.gov/pubmed/20929406

https://www.hindawi.com/journals/bmri/2013/725410/

I developed full blown thyroiditis a few years ago and it correlated to when I stopped taking Sprcyel for nine months. Taking Sprcyel or stopping sprycel can impact the thyroid.

My suggestion is to not depend on your oncologist - he doesn't know. It would be wonderful if he would just admit it. You need to see a thyroid specialist who will likely prescribe thyroid hormone to boost your T4 levels and lead your TSH lower. Also - consider a daily iodine supplement (kelp). You want to be sure you are getting plenty of iodine to help your thyroid do its job.

(edit: 11:30 a.m.)

 

I second the idea of seeing an endocrinologist.   My first oncologist saw no reason to check TSH for six month.    I asked my current onc to test and my TSH has increased to over 10    A week later it was 12. My endo increased my levothyroxine by 30% and my levels quickly responded. 

 

I personally would see no reason to wait things out, especially when it’s an issue which can be easily addressed.   

Hello. Hope you all are doing well.

I have been on 50mg sprycel daily for the last two years, and lately been having some issues like chills, dizziness, tinnitus and muscle/join pain. Dizziness and tinnitus started about 2 weeks ago, and been having muscle/join pain the last 8 weeks.

I have also been battling a cold on and off for about 8 weeks, and now 2 weeks ago i got Covid. I also must mention i had a bad round of depression and bad anxiety (fight or flight) about 8 weeks ago, lasting 2 whole weeks. I think the anxiety is because my sister died of breast cancer 11 months ago, she was a young woman in her 30`s, with 2 small children to care for, and this has hit me very hard.

I went to the doctor, she took a blood samples (they said they checked "everything") and they came back 1 week ago, all levels well within reference, and everything was normal, except my TSH, which was slightly above the reference value. (The test was taken in the morning, before i took my sprycel)

My question is: Could my elevated TSH levels be the cause of my chills, dizziness, tinnitus and muscle/join pain or is it more likely something from the covid? (Or maybe both?) I seem to just have a "minor cold" left from the covid now, but my above symptoms are still with me, they come and go from day to day.

Any thoughts would be greatly appreciated, thanks smiley

 

My PCR Values:

Month - PCR

01 - 76 Started Imatinib 400mg
02 - 13
03 - 3
06 - 0,1
09 - 0,02
12 - 0,03
15 - 0,04
18 - 0,01
21 - 0,01
24 - 0,01
27 - 0,03
30 - 0,01
33 - 0,03
36 - 0,01
39 - 0,01
42 - 0,01
45 - 0,01
48 - 0,01
51 - PCRU
54 - 0,015
57 - PCRU
62 - 0,020
63 - 0,020
66 - PCRU
69 - 0,018
72 - 0,007
75 - 0,004
78 - 0,004
81 - 0,017
84 - PCRU
87 - 0,004
90 - PCRU
92 - PCRU
94 - 0,005 - Switch Sprycel 50mg
97 - PCRU
101 - 0,002
105 - PCRU
108 - PCRU
112 - 0,004
115 - 0,012
118 - PCRU