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High WBC - cml progressing??
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Not enough information.
What is your PCR level? What is your blast cell count (percentage)? What are your other blood counts in absolute numbers (not percentage)?
Hi Scuba
I am on Tasigna 400 mg BD since an year. My last PCR 25 sep - 0.0078
I actually missed a dose(evening) 07th dec so took an CBC today.
CBC report : 11 Dec
Hemoglobin. : 15.3
TLC : 16000
Neutrophils 70%
Lymphocyte : 18.5%
Esonphils. : 3.5%
Monocyte : 7.1%
Basophils : 0.8%
On 20th Nov : TLC : 8800
Kindly suggest. I am really worried.
On your CBC, it should show ABS numbers (ABS = absolute). Can you report those ....
Your white blood cell count is showing a sharp rise which could easily be caused by an infection you may be fighting.
You could be losing response, but given that you PCR from a few months ago was excellent (i.e. < 0.01%), it seems unlikely that you would lose response this quick and then have symptoms (i.e. blood counts) show up.
What you must do is get a PCR test (bcr-abl) right away (and FISH as well). Without fresh PCR data, we are guessing.
Ohh okay. My CBC couple of weeks back was good around 8800. Is it possible to lose response so quickly.
Not really - it is, however, very possible for WBC's (leukocytes) to jump dramatically in the presence of an infection including pregnancy for women. 16,000 - 18,000 is not unusual in those cases.
Hi, yes. Worried a bit
I got my CBC report today again. Here are the latest values.
Last week - TLC was 11.53 and today it's 11.14
Lymphocytes have increased from 28%(abs 3.24) to 42%(abs 4.73).
Not sure what is causing increase in lymphocytes. Kindly share your thoughts.
Differential Leucocyte Count (DLC)
Segmented Neutrophils 43.00 % 40.00 - 80.00
Lymphocytes 42.50 % 20.00 - 40.00
Monocytes 8.50 % 2.00 - 10.00
Eosinophils 5.30 % 1.00 - 6.00
Basophils 0.70 % <2.00
Absolute Leucocyte Count
Neutrophils 4.79 thou/mm3 2.00 - 7.00
Lymphocytes 4.73 thou/mm3 1.00 - 3.00
Monocytes 0.95 thou/mm3 0.20 - 1.00
Eosinophils 0.59 thou/mm3 0.02 - 0.50
Basophils 0.08 thou/mm3 0.01 - 0.10
Platelet Count 207.0 thou/mm3 150.00 - 450.00
But that's lower than the last time you wrote, so you went down from 16 to around 11.5, right?
Your general counts seem much much better than last time.
From your absolute counts, neutrophils seem to be very much normal.
I'm not the expert here, but I see that you have a bit high lymphocytes (again, as an absolute number), which do not increase in CML (I think they belong in a different white blood cell "family").
What does your doctor say?
I’m in the same boat with my lymphocytes increased to 6.78 when I had bloodwork last week with wbc count of 12.8
my next bloodwork is on monday 12/23.
I read online that Dasatinib induces lymphocytosis with in 1-2hr window after the pill is taken and normalizes after that. Google “dasatinib lymphocytosis nature”
I had emailed Dr cortes and he said not a major concern. He was aware of the fact dasatinib causes lymphocytosis.
Next time i’m planning to take the pill after the blood is drawn to see if that makes difference. Fingers crossed..
Hi Korila,
Yes, My first CBC showed TLC - 16000.
I had to get CBC again at NABL accredaited lab to be sure on the count. That's when I got 11.53 with abs lym count : 3.54 dated 12 Dec
On 17th Dec I took CBC test on the same NABL accredaited lab for comparison in which TLC is 11.14 (Slightly reduced) however abs lymphocytes increased(4.73).
Many thanks for checking in