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After the blood count dropped, what did the doctor do? halt treatment until blood counts came back? re-started at full dose when they did come back?
A BMT should be the absolutely last last resort. As long as your wife's blast cell count is low (< a few percent), she has time to have dose adjustment to enable blood counts to adjust.
(I had severe CBC suppression - severe. Each time, my doctor had me stop taking sprycel and wait until blood counts recovered. During that time, my PCR plateaued and blast cells were a few percent. He told me we (him and my body) had time to adjust. After my blood counts recovered, I re-started sprycel but at a FRACTION of the original dose. I still had suppression, but it was less severe. I stopped therapy again and then re-started at the lower dose. This happened a few more times, but finally, I was able to stay on drug and my blood counts were stable. Albeit, lower - but a new acceptable level. After staying on drug for 3 months continuously, my PCR plummeted. I am "undetected" today at 20 mg sprycel)
Typically they would stop the tki until her platelets went above 50, witch sometimes took 3 months. This is what we have fought now for a year and a half. I believe she’s tried 5 tki’s all with the same result in a couple of weeks. I’m pretty worried and don’t know what to expect. On the positive side we found a 💯 match from a older brother.