https://principia-scientific.com/uk-government-releases-shocking-report-...
The highest incidence appears to be cerebral/eye disorders. One in ~300 chance of an adverse event.
Unfortunately, we don't know who is likely to be susceptible to an adverse event.
Hi Scuba,
I think your last observation is the relevant one.If one were willing and able to screen all of potential patients to be vaccinated for prior medical conditions then there is the danger of blaming the vaccine for the adverse event-in terms of the optic events mentioned I would ask how many had prior sight issues such as macular degeneration which as we know if not treated can lead to blindness.
On a general basis,only a personal opinion but,the general health of the UK population is quite poor;I have looked at OECD data on obesity and we are not far behind USA,Mexico and Portugal is nearly on a par with us;add in being overweight,diabetes,pulmonary issues such as asthma,cardio pre conditions we are not in a good place.Preventative medicine in UK is not in a good place either.
On a personal basis when some weeks ago I had the Pfizer jab the screening was minimal and focused on being on blood thinners such as warfarin or heparin and also previous allergic episodes;my CML and tki were judged to be not a problem.My reaction was very light.My partner much younger than me and Thai ,as a carer, was given Astra Zenica a few days ago and is having some considerable side effects but all in line with government advice and with no need for medical intervention;her immune system is reacting quite strongly.
At a societal level UK scientific advisers and politicians hope that the take up of vaccines say up to at least 80 per cent plus of the population will lead to some sort of herd immunity developing.On a personal level my own risk analysis is that given my age if I contract Covid I might not survive so if the vaccine means that if at worse I get a mild version and also avoid hospitalisation then great.
I would suggest that we run similar risks with tkis. Nilotinib is hard on the heart but how many patients are screened with an ECG prior to being treated with it? For Dasatinib if one has had any prior pulmonary illness then it might not be for you as it could lead to higher risk of pleural effusion-how many have a CT scan prior to being treated with this drug? The last line tki Ponatinib has a black box FDA warning on it due to vascular events so in the event of a fatal adverse event do we blame the drug or the prior condition or both?
I would conclude that in terms of side effects of a drug / vaccine/ procedure we need to take account of co- morbidities and prior health issues-but that takes time and resources.
Regards
John
A Google search into Principia Scientific would suggest a need to exercise caution with anything they write.
I’ve been logging daily with an app run by Kings College London which has been tracking COVID data since the beginning of the pandemic and they provide interesting updates and insights based on real time data. The lead scientist gave an update on the vaccine rollout in the UK the other day. An interesting snippet I noted was that reported sided effects were greater after the second dose than the first. However, they saw this in the clinical trials too - in both arms! In other words, greater side effects after a second dose of placebo, too.
Given the huge number of people vaccinated in the UK now it’s unsurprising that some are reporting “adverse events”. But they’re most likely reporting health events which are nothing to do with the vaccines.
I also use the Kings College (ZOE) Covid symptom study app and follow with interest insights based on their real time data. As Richard has very helpfully pointed out, they have seen an increase in reported AE's after the second doses of vaccines, which is reflected in the clinical trials data... i.e larger numbers of reported side effects (|Adverse Events) after the vaccine (2nd dose) but crucially this includes those who have had a placebo, so cannot be vaccine related.
This ties in with John's point about the need to take into account pre-existing medical issues....and his caution against the assumption that all AE's are or will be, vaccine related.
Sandy
ZOE Covid Symptom Study - Webinar summary 'Are the vaccines working? What after effects are people experiencing? We reveal our first findings'
Log your vaccine, help the NHS here: Vaccines
