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Living with CML:lifestyle/ nutritional response

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Hi All,

For some time like others perhaps I have been considering whether there are any actions or any additional medications that might help to maintain or improve the response to a tki and to develop perhaps a deeper remission.There have been a number of medical responses in the form of research to ascertain whether combining another drug with a tki might be useful-so called combination therapy.Examples are antibiotics such as tigecycline that back in 2017 was being investigated by University of Glasgow for instance.As well we have ideas on the use of more natural elements such as turmeric,circumen and resveratrol (red wine/grape skins) for instance.Next down the line are a range of perhaps more questionable and non proven remedies.

In my current reading I came across "The Diet Myth" by Professor Tim Spector; he of course is involved in the ZOE Covid symptoms project separately reported on Forum recently.He has another publication called "Spoon Fed" but I have not read it yet.I found his book easy to read yet at the same time very much based on science and the scientific method using references to a range of studies and meta data -with an intent to develop workable algorithms and possible future AI applications.

I have read others such as "Lifestyle after Cancer " by Professor Robert Thomas who also wrote "How to Live";he is an accomplished oncologist working in the NHS at Bedfordfshire and as well Addenbrookes,Cambridge.He is involved in trials and research re the benefits of polyphenols and plant based foods.He suggests that some vitamin additives such as for A and E need to be treated carefully as overuse  and overdose can lead to antioxidant stress;the key seems to be get tested then address it via supplements and /or diet .Others it seems like Vit D if overdosed will be excreted normally;potassium overdose might affect kidney function and so on.

I saw a You Tube presentation by Tim Spector who when asked about Diet/Nutrition Myths said Number one Myth was the" Calorie" as on labels or in restaurants the data was often inaccurate or more importantly it might not apply to the individual. He said that the gut microbiome (pre biotics and probiotics ) were critical to the immune system;re Covid implications research was ongoing.He did say that poor nutrition and obesity  present enhanced risk factors but that the link between poor diet and infection needs greater exploration.He explored the theme of food =medicine but concluded that eventually we will need personalised nutrition plans and what is the healthy food for you? At the end it might be all about genetic variation and be difficult to generlise about.

Has anyone else tried to explore the science using published papers or data regarding how one might fortify the benefit of the tki via lifestyle and food?

Regards

John

Hello, regarding this topic it seems convenient to mention some information that I found interesting, which I found in Dr. David Servan-Schreiber's anti-cancer book and talks about certain herbs and spices that apparently could act in a similar way to Gleevec. Below I attach the text where it is explained; (It is translated from Spanish to English, I hope you understand) :

^ Gleevec blocks the cellular mechanisms that allow cancer to continue to grow day after day. It acts on one of the genes that stimulate cancer growth, but at the moment it is believed that its main function is to block one of the springs that stimulate the creation of new blood vessels: the PDGF receptor. Administered daily, Gleevec can "contain" the growth of cancer, thereby rendering it unsafe. As Judah Folkman, the discoverer of angiogenesis, says, we have reached the stage of "cancer without disease".

Well, it turns out that many herbs and spices act similar to Gleevec. This is valid for the Labiadas family, for example. In this family are classified: peppermint, thyme, marjoram, oregano, basil and rosemary. All of them are rich in fatty acids of the terpene family, which are what make them so aromatic. Terpenes have been shown to act on a wide variety of tumors, reducing the spread of cancer cells or causing their death.

One of those terpenes, rosemary carnosol, affects the ability of cancer cells to invade nearby tissues. When it is unable to spread, the cancer loses its malignancy. What's more, researchers at the National Cancer Institute have shown that rosemary extract helps chemotherapy penetrate cancer cells.

In Richard Bélievau's experiments, apigenin (abundant in parsley and celery) has been shown to have a powerful inhibitory effect on the creation of blood vessels, necessary for tumor development, to a degree similar to that of Gleevec. This effect occurs even at very small concentrations, similar to those seen in the blood after having eaten parsley. ^

That said, I wonder if a diet rich in celery as well as spices such as parsley and rosemary could help someone with their results or even be useful to maintain TFR in someone who wants to try it since their disease is very controlled. Personally, I don't think there is much that can be done about it beyond taking the pill every day, however it seems to me an interesting investigation and to take into account, I hope it has been helpful, greetings.