My most recent PCR test came back at an increase from 0.005 to 0.034. I moved from 50 mg of Sprycel to 40 mg in November when I received the 0.005 result. I deal with numerous side effects on Sprycel. Irregular Heartbeat, Occasionally short of breath, Fatigue in my legs mostly that doesn't persist all day. I can be fairly active without issues. I take Metropolol (beta blocker), Linsinopril (Blood Pressure) to help with side effects of Sprycel. I take Magnesium, K2D3, Curcumin Tumeric and B12 regularly. I also have to take Pain Meds(Norco) regularly to help with pain and fatigue. I have desires to make it to 20 mg of Sprycel in hopes of getting rid of some side effects. I have had a couple of blips in my results the previous very minimal .016 to .022. I know that I have responded quite well to the medication thus far. I am 17 months post diagnosis.
My concern here is the uptick was quite a bit bigger although it doesn't seem to be winning any races as my last result was 4 months ago. I like most am extremely anxious about upticks. I do not have a great attitude about my illness it can be quite crippling at times. I am hoping that someone can offer me some advice for dealing with these situations. I am 35 with 3 girls and my wife to try to care for. I am still learning to be a father and husband and I mostly try to work hard to provide for my family. Our lifestyle has me as the only one making money. It is a tremendous responsibility that weighs heavily on me. Adding this illness has made things very difficult, and I often want to run away from my responsibilities. I can get quite selfish during these emotional times. My wife expressed that she has a difficult time discussing my CML as she is very anxious herself. I am hoping my results turn around on my earlier than usual PCR 48 days after my previous. We will see. My doctor doesn't seem overly concerned but is taking action in ordering labs earlier. I just need someone or a group to talk to. I do not have anyone to talk to that understands my circumstances. Please offer anything. Also could someone explain to me if this is considered a log increase?