Treatment Free Remission (TFR) information:

Treatment free remission (TFR) is successful in about 50% of patients who have been in DMR (undetected) for over 3 years. What was clear to me is that CML re-starts due to quiescent leukemic stem cells (LSC) which come out of quiescnence (at some point) and begin the CML disease process all over again in the absence of a TKI. This partially explains why the longer one takes their TKI and is "undetected" higher the success rate of TFR.

My research before attempting TFR focused on natural ways based on the biochemical pathways favoring LSC's, to eradicate or render ineffective the remaining LSC's. My hypothesis is that population of the LSC compartment is critical to LSC survival, expansion and subsequent disease. People who are successful in their TFR attempt probably had their LSC's divide for some reason and then their TKI killed them. LSC's are susceptible to TKI apoptosis when dividing only (TKI's bind to the ATP site which kills the cell, but only when the cell needs energy during division).

How to coax LSC's to divide? Fasting depletes white blood cells. Re-feeding following a 3 day fast (water only) triggers blood cell regeneration (i.e. stem cell's divide, come out of quiescence) sufficient to regenerate the entire immune system:

• https://www.flowin.com/index.php?page=blog_post&blog_id=79

So I started a fasting regimen while taking dasatinib. I did this 3 times. Each time I envisioned whatever LSC's I had, were "whacked" when they divided.

LSC's also are inhibited and destroyed by the action of selenium:

• https://pubmed.ncbi.nlm.nih.gov/24872387/

I started taking 200 mcg selenium per day both before and after I started my TFR attempt. I continue to take selenium and will for the rest of my life. May help prevent other cancers.

I take Curcumin, maintain high normal vitamin D (60-90 ng/ml) and otherwise focus on a ketone based diet instead of carb based. Cancer cells do not process ketones well, but thrive in a glucose rich environment. I feel better too.

Doing the above, it is my hope, tipped the scales in my favor in having a successful TFR. So far so good. If I remain "undetected" for another 4 years, I will consider myself cured. But will still test once per year just to be sure.

By the way - my confidence is high because I continued to fast multiple days and then re-feed during my TFR this past year. If LSC's still existed at a critical level, then in the absence of my tki, they should have expanded significantly to re-start disease as re-feeding occurred. I was watching for that and it apparently did not occur. Instead, my normal HSC's (blood stem cells) repopulated my immune system.

p.s. There is a downside to a successful TFR. My wife no longer shows me sympathy as a "cancer patient".

Hiii.... Scuba... 👍👍👍 My last pcr UNDETACTABLE.. (report (September 2021)(next report in April 2022) 

December  000 dose

January      000 dose

February.    400 (600 to 400 discrease                                       dose)

March.        400 imtinib

32 HOURS WITHOUT FOOD WITHOUT WATER...   Once in month (last 4 months) (4 TIME)

Next pcr in April 2022 

10 YEAR.... UNDETACTABLE

WITHOUT WATER LSC FAST DIVED.. (MY THINKING)

.. BUT. DON'T TRY....

THIS TIME IN INDIA SUMMER START....
STOP... FAST WITHOUT WATER.......