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Is there a possibility to be off Dasatinib and try to concieve ?
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Yes. I know several women with CML who were taking dasatinib, stopped therapy, conceived and gave birth to healthy babies (twins in one case!).
Their CML did start to rise again, but stayed in chronic phase for the nine months plus a few months for breast feeding. After that period, they resumed their therapy and quickly regained remission.
The only significant issue is blast cell counts need to be very low or zero. As long as blast cells are under control, CML is a very slow disease.
For women? It’s perfectly advisable once you stop taking dasatinib assuming your numbers are low enough to support TKI withdrawal. As Scuba says, dasatinib has a short half life so it is virtually all flushed from your system within 48 hours.
The dasatinib part of the decision isn’t the difficult bit, it’s whether your CML can be controlled without a TKI for the duration of pregnancy (and any resulting breast feeding desired).
David.
Hi, I have spoken to my oncologist and two fertility specialists about this, and they mentioned being maintained on interferon injections for the duration of pregnancy. I think it depends on your levels, as mentioned by others, but also on your age and your AMH levels. Have you had a fertility workup? I would recommend doing that now. There are a few programs (at least in the US, and I'm sure internationally as well) that you can apply to for financial assistance if you want to move forward with IVF or a similar ART if getting pregnant right now is not an option. You are considered for these programs especially as a cancer patient, given the prohibitive cost of IVF and other alternative forms of conception (surrogacy, etc).
Hopefully you can consult with your oncologist and they can refer you to a good OBGYN, or a few, who specialize in fertility and/.or high risk pregnancy.
Good luck!
O