Hi all. I'm after some advise again please. As previously mentioned I have been taking Imatinib since my diagnosis of CML for the past 5 years. Over recent months I have experienced 2 infections which required antibiotics and now, more recently I have been experiencing frequent cramps which have become more painful, along with breakout small bruising, and one week ago developed first one then another large haemoserous filled blisters on my lower leg for no apparent reason. No friction or trauma. I had blood tests 2days ago and was told no real change. I am due to speak to my consultant over the next few days and am wondering if a change of medication may benefit me. I realise that only my consultant and I can decide this but is there anyone on here has had any similar experience.TIA