hello,
(sorry i have not followed up on my recent post in another/different subject.)
what what measures determine chronic phase to accelerated phase?
i mean, if your in chronic phase, then they say you are now in accreted phase: what line or lines did you cross?
thank you
Hi, Tedro. From the LLS CML Phases and Prognostic Factors:
In the accelerated phase, the number of immature blast cells has risen, and sometimes new chromosomal changes, in addition to the Ph chromosome, will occur.
People with accelerated phase CML may have:
More than 20 percent basophils (type of white blood cell) in the bloodstream
More then 15, but less than 30 percent blasts in the blood and bone marrow
Low platelet counts unrelated to therapy
Increased spleen size
Worsening anemia (caused by low levels of red blood cells)
Additional chromosome abnormalities in the CML cells
In the accelerated phase, the number of CML cells grow faster and cause symptoms such as fatigue, fever, weight loss and an enlarged spleen. If untreated, accelerated phase CML will eventually transform to blast phase
WBC has little to do with blast vs chronic. Very high counts and an enlarged spleen can be indicative of blast crisis but its not the determining factor, as far as i remember the hematologist determines blast or chronic phases by looking at the blood cells.
I had 330,000 white cells per microlitre and was in chronic phase. Normal range is 4,500 to 10,000 and without leukemia or lymphoma a wbc of 20,000 would indicate a severe and debilitating infection.
