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TFR question

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My Doctor wants me to try TFR next year.

Diagnosed in August 2018.
Reached MMR in 9 months on sprycel 100mgs.

For the last year I have been in a 4 log reduction while being on 80 mgs of sprycel.

9/2024- .0035 %
11/2024- <.003 % ( test cannot detect anything less than .003)
1/2025- .007%
3/2025- .0058%
5/2025- <.003%

My question is do I stay at 80 mg and try TFR next May. Or do knock my medication down to 50mg and eventually 20 mg before I try TFR. My doctor is willing go down in dosage but also said since maybe I stay on 80 since its working and I have little side effects.

Hi,

Every time someone asks a question like this I suggest looking at this video; it is getting a little old now, and its main focus is on imatinib patients, but I hope it is useful. https://cmlsupport.org.uk/videos/reducing-or-stopping-treatment-who-and-...

Thanks ill take a look

I just came off a TFR attempt in the last year and found that the type of transcript you have, e13a2 or e14a2, can be a deciding factor in the sustainability of remaining in TFR.

JP

I am not sure how to fin out if i am either of those. I dont remeber seeing that info on my FISH.

You will only see different transripts identified on a BCR-ABL test. FISH can't differentiate down to a microbiology level. The results you quoted above are from a BCR-ABL test.I you have the full report on those results it should list the transcripts they found.