Nilotinib has been associated with increased risk of peripheral artery disease (PAD), 1–3 coronary artery disease, and cerebrovascular events. 4–6 We present the cases of 3 patients who experienced ischemic strokes during long-term treatment with nilotinib.
i was diagnosed with CML 22 years ago. was put on nilotinib in 2014. i had 2 strokes TIA in 2020. its been investigated and found that the drug caused this to happen.my blood pressure was not checked as it should have been. i didn't see an hematologist for 6 years just saw a nurse specialist. I'm now for the last 5 years in a wheelchair cannot walk, work or drive .please if you have any problems see your doctor asap. I'm now taking bosutinib.
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nilotinib and stroke risks
Hi, I appreciate your post on Nilotinib - I have pushed my doctor to change to another tki. I'm starting with Dasatinib.
Among other side effects I was constantly fighting with breathing normally, heart palpitations and pain, high blood pressure and terrible fatigue.
Thought my doctor is sure that I am more under psychological effects than drug influence - he has prescribed Sprycel now. I have stopped taking Nilotinib 8 months ago - just stopped.
Blood test is showing good numbers now - better than lots of people of my age have.
Unfortunately the BCR started to croll up. Slowly but....
Thanks again. Good luck with new treatment!