After 3 years on IMATINIV 400 doc shifted to PONATINIB 15mg and is now BCR-ABL 0.000 not detected. But my HBA1C and blood pressure are getting wild and it’s 7.3 and 150/95 after taking SITAGLIPTIN, METFORMIN, GLIMPERIDE. What’s the way out of this situation. Should I ask doc to reduce the PONATINIB dose.
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I believe 2 of your meds are broke down by your liver,sitagliptin and glimperide. it could be your liver is having a harder time ridding your body of the ponatinib {broken down by your liver} so the ponatinib hangs around for a longer time in your body. 10 mg a day may be plenty for you. and maybe you and your doc could discuss accepting a lower bcr/abl for sake of your liver and pancreas and other organs.
Just because you are undetected doesn’t mean there are no copies left of BCR/ABL in your system. Although you are at 0.000, you could easily be at 0.00001 or something like that. The tests are just not that sensitive. I think you could afford to lower your ponatinib dose. Your numbers may rise and even get within detection range but you are well below MR3 so a reduction can be attempted in my opinion. Hopefully a lower dose will get rid of some of those side effects. You may have to live with a higher number but with far less stress from the side effects.
JP