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Glivec Failure

Hi all,

I was DX in October 2008 with Chronic Phase CML, I had a marvelous response coming from 113.553% baseline to 0.468% which was my result in April 2009. However in my July PCR it came back as an increase to 18.204%.

I had the standard retest done which came back at 48% which I guess is a definate Glivec failure. I have had a BMA done last week and they are currentley carrying out a mutation test at the Hammersmith.

I know that there are many individuals that fail Glivec and move onto other TKI's due to mutations etc. Does anyone have an experience similar to this as I would be interested to understand what your approach, actions etc were.

I want to makesure that I am asking the right questions and making sure the right tests are being done. I know we have many long term CMlers on the site and would appreciate any information experiences you may have.

Best wishes

Mark

Couldn't have been more delighted when they told me that Glivec just wasn't working for me. At 56 I had spiralled into old-age. Am now on Dasantinib and feel very much better for it! Having a bit of a job with one of the side-effects, but as I will be pitching up for help with that tomorrow, I won't say any more just now.
Keep your pecker up, I'm sure Sandy will be along to discuss this more formally with you and to give you the advice you need.
I've been on Dasatinib since Glivec failed in February and will know in a few weeks time if it doing its job or not!
Vickie

Hi Mark

My experience was not unsimelar to yours in that Glivec worked wonderfully for the 1st 20 months after DX in January 2006 that my PCR went from just under 2% up to 81% I am now on Tisiga since January this year and my latest PCR in July was 12% so my Onc is happy with the result and the steady drop in my PCR is positive. My next PCR is in early Sept so lets hold thumbs.
All the best for your future PCR drops

Trevor

"A Moment missed to give is a moment missed to receive"