This week I went to the Hammersmith & saw prof Apperly, what a great lady she is. We had a in depth discussion about my reactions to the TKI'S and the way forward to manage my cml. The plan is now to stop Dasatinib, have high dose steroids for 2 weeks, restart Nilotinib at 200mg once a day supported by steroids. I have done something similar before with no success but it is worth a go again she thinks. Any adverse skin reactions I must stop treatment. The Prof is going to ask for Bosutinib on compassionate grounds. As they have trialed it at the Hammersmith she thinks they will stand a better chance of obtaining the drug rather than my local hospital. If Bosutinib fails me then the next course will be Interferon, not peglated to start with & if all else fails the last option will be a transplant. so, at least now there is a plan of treatment.
I wonder if there is anyone here who has had Bosutinib, I would be interested to hear of any experiences with this drug?
Many thanks.
