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Multi vitamins and Glucosamine Sulphate

Hi All,

Until diagnosis with CML took a multi vitamin and 500mg Glucosamine Sulphate for joints as play a fair bit of squash. Does anyone have any knowledge whether these tablets will have an effect on Glivec at all as I have found them very good for joints ?

Thanks  Nigel

Hi Nigel... I am not aware of any problem with multivitamins/amino acids/vitiamin and mineral supplements in general have any adverse interaction with imatinib.... my advice would be that you should look at them as supplements to your diet and as such are of positive benefit. If you have found this to help with joints etc and general fitness then carry on.... but if you are worried check with your haematologist.

We do know that you should take the following:

do not take: antacid preparations with or near to taking imatinib- 

do not drink grapefruit juice or eat this fruit- this is true of nilotinib (and maybe dasatinib?) -it seems that an enzyme in grapefruit (and I think seville orange as well) which increases the plasma levels of the TKI- hense this would impact on the severity of side effects.

do not supplement with St. John's wort- this affects bioavailability of the active compound too.

There is quite along list of other pharmaceuticals - I will dig it out.

This is an interesting study on sodium potasium levels- not in CML - but generally for cardio vascular health.

Best.. Sandy

 

Less Sodium, More Potassium: A Better Balance 

 

The connection between sodium intake and the risk of death hasn’t always been clear. However, a study in the Archives of Internal Medicine recently found that there is more to the equation than sodium alone. Potassium, found especially in fruits and vegetables, can offer some added protection against dying from heart disease. 

The new study used information from 12,267 US adults, in which they recalled what they ate over the course of a day. The study was part of the Third National Health and Nutrition Examination Survey Linked Mortality File, investigating the influences of sodium and potassium on the body. They were also looking at the ratio of sodium-to-potassium in the diet, cause of death, and heart disease over the course of 15 years. From the dietary recall information, researchers estimated usual daily intakes of sodium, potassium and calories. 

The study showed: 

  • Higher sodium intake was associated with an increase in mortality from all causes.
  • Higher potassium intake was associated with a lower mortality risk: people with the highest potassium intake had a 61% lower risk of dying from all types of cardiovascular disease and a 74% lower chance of dying from ischemic heart disease (heart disease caused by impaired blood flow, usually a result of atherosclerosis) compared with people with the lowest intake.
  • Having higher sodium-to-potassium ratios significantly increased the risk of mortality from heart disease. For ischemic heart disease, the risk was more than two times greater among people with the highest sodium-to-potassium ratio than in those with the lowest ratio.

“From a public health point of view, reduced sodium intake accompanied by increased potassium intake could achieve greater health benefits than restricting sodium alone,” said lead study author, Quanhe Yang from the Office of Public Health Genomics at the Centers for Disease Control and Prevention.