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MMR will it ever happen?

Hi all,
I'm interested to hear from others who may have taken a while to reach MMR.
I've been taking part in a trial for over 2 years now(diagnosed Sept 2010.)
Started on Glivec for first 6 months and then moved to Nilotinib.
My latest PCR is 0.12
Previous results;
0.48
0.53
0.16
0.19
They tested for PB? mutations and none. I had to take a break from Nilotinib due to raised liver enzymes in 2011 but have been back on with no problems or side effects since Nov 2011.
I just feel like my results really creep along and it is frustrating.
Anyone else feel the same? I can't complain as I feel well, just thought I might have got a few more zeros under my belt by now and we were also hoping for another baby one day.
Thanks
Kate

Sometimes it can take a while for the tki gets the patients to MMR.

Here are some statistics: http://community.lls.org/thread/11781

Seeing you had 2 tests at around 50, then a drop to 16/19, then 12 i would think there is a good chance that one of your next 2 tests will be MMR. Trends are important, and your looks good :)

Teddy

Hi Kate,
First let me say that I do understand why you feel frustrated- especially as you want another baby, your journey to MMR must seem slow! But, I agree with Teddy, you are showing a downward trend, maybe slow but it is steadily reducing.
And now your latest result is 0.12? Well that is virtually MMR according to the international scale:
MMR = 0.1% (or a 3 log reduction).

Of course it depends whether the lab where your PCRs are done uses the international scale- maybe you could ask.

Nevertheless, you are doing very well as you do not have problems with nilotinib and your % is on a downward slope, fingers crossed that your next PCR will show a further drop.

As long as you carry on with your therapy and take it every day I am sure you will see a deeper MR with time.

Sandy

Thanks so much for your encouragement Sandy and Teddy. Had a look at the stats on that site, very interesting. Lets hope slow and steady downward trend will continue. I'll be sure to post on the forum when I reach the elusive MMR.