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Rash

Hi all

Hope you are all well. I have been on nilotinib now since July and feel well however I have suddenly developed a raised red rash on my back should I be worries or go to the docs

Thanks x

Although I do not have personal experience of 2nd gen TKIs, I think this is a common side effect of nilotinib- although ponatinib also has rash in its list of side effects but I am not sure whether they are the same kind of rash. I am sure there are many others that can answer you better than I- but unless the rash is causing you problems and is hard for you to tolerate- I don't think you need to be overly worried. If the rash worsens then you should of course phone your clinic.... sometimes with a higher grade of side effect, a short break in therapy seems to solve the problem, but of course you would need to ask your doctors opinion first.
Otherwise you could try a natural based cream that might help sooth the rash. If it is raised then maybe homeopathic remedy based cream like Rhus Tox -available in good chemists or online- might help. It would certainly not do you any harm.

I do hope others who have more experience with TKI side effects than I do, will take the time to answer your post.

Sandy

Per what sandy said, a rash is quite normal on tasigna. My skin has changed significantly but on the whole has settled to a manageable level. My advice would be to use some E45 and see how it goes. If it gets worse then you may wish to have a chat with your doc. I hope that helps.

Chris

In the first year of my treatment with Imatinib, I came out with really bad rash all over the place - cracked and bleeding. It has since subsided, but my GP suggested Doublebase cream and it works well. It is available over the counter or on prescription.

I also find, very strangely, that exposure to sunlight helps. If I go somewhere hot in November to restore a tan, it keeps the rash down through the winter. Someone will say that Glivec reduces ability to produce melanin and you burn more easily. I've found that to be true, but, although I burn more easily, I can still tan, albeit less than before. I guess the Glivec effect is because apparently melanin is formed as part of the process of metabolizing the amino acid tyrosine.

John