I changed to Dasatinib on 17/4 after a complete break, and then a change to a dose of 300 mg Imatinib to try and cure Fatigue, Insomnia, and low moods. Several new side effects, but much better in general and easier to tolerate it seems. Initially, they looked to put me on Nilotinib due to the reported much better side effect profile, but Dr. Marin sought approval for Dasatinib on the basis that I am middle aged, and will have to take the drug for many more years. He had concerns as in the posts below, of the risk of Arterial Schlorosis with Nilotinib. Would have tried it though, as the lower dose Imatinib didn't help me.
Positives - better sleep & much more energy, generally feel much better on Dasatinib. Negatives - losing body hair on the arms and legs in particular, rashes on the top of the head, neck, arms and legs. Not much on the torso. Most significant - Palpitations at rest, never had this before. Sent for an ECG at the HH Monday just gone - Normal. Reduced my dose from 100 mg Dasatinib daily, down to 50 mg. Go back to three monthly check ups. If the PCR shows an increase in BCR-ABL, will increase the dose again.
Hope this is helpful to those experiencing similar issues, and considering changing TKI's.
Phil.