Dear Sasha,
I am answering you on a new thread for this subject as the old one has quite a few posts on it and your post might not be as visible as it should be.
First and foremost. In your situation- i.e. your husband is the one who is being treated with TKI therapy, the news is good. TKI's do not affect sperm and so his therapy will not be an issue for you. I recently had a private email on this very subject asking for advice from a couple who are in the same situation. Their consultant did not feel he could advise them as he was not aware of the data regarding TKI therapy and its possible effects on sperm. Therefore I contacted my consultant on their behalf and she confirmed that there is the same level of risk of foetal abnormalities for males on TKI therapy as there is in the 'normal' male population. In other words, go ahead with your plans.
Of course for females it is a different issue- although there have been normal births to women who have found themselves pregnant whilst taking TKI therapy there have also been a number of abnormalities and/or miscarriages. TKIs can affect the development of the foetus if it is exposed during the first 3 months of development. It is advised that women who plan to get pregnant wait until the PCR results show a stable molecular response, and then stop taking their treatment for the duration of the pregnancy, with close molecular monitoring during this time.
I suggest you talk with your husbands doctor about this and if he/she is not able to confirm the above data regarding males, then let me know and I will try to advise you further. You can always ask for a referral to Hammersmith if you want to talk and confirm the background to this subject with the doctors there. Let me know if this would help and I will send you contact details privately.
Sandy
recently pregnant
Submitted by sblan on Tue, 03/06/2014 - 05:20.
I know that this was posted several years ago, and I am really hoping that someone reads this, as I am in hopes to get good news about the pregnancy's I have read about in this forum. I was wondering if you could enlighten me on any information and Dasatinib 100mg a day and pregnancy outcomes.
My husband was diagnosed almost a year ago and we just found out that I am pregnant. He was on tasigna before and had a small break and in the last 10 weeks started on Sprycel. As this is our third child, and very unexpected we are trying to gather as much info as possible about this pregnancy.
any thoughts or info is welcome.
Sasha
ยป
Dasatinib and pregnancy
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Submitted by louisealdridge on Fri, 06/06/2014 - 21:05.
Hi Sasha,
My husband was diagnosed in 2005 age 34,he had two years on imatinib then put on to dasatinib 140mg in 2007, as we already had one child and therefore not eligible for fertility treatment, the hospital sent us to a local fertility clinic for some tests on his sperm, of which they said there did not appear to be any problems so we were advised to go for it.
I conceived naturally at age 41 a few months later, and at 20 weeks the hospital did a thorough scan of the baby and there were no apparent problems, in fact they seemed more concerned with my age than the dasatinib effect on the baby.
We had a healthy girl in Dec 2010,who is now 3 1/2, and has brought us much joy,and is still healthy , i think you will no doubt worry through the whole of the pregnancy as we did, especially as my husband had been on the medication in total for 5 years at the time and no one new the impact on the foetus.
When you do go for your scans just mention his medication and make sure that they scan you thoroughly, and good luck, I hope our experience will help you.
Louise
