Hello my mother has CML since last 6 years, since then she is on daily dose of generic variant of Gleevec ( Ibatkin 400mg)
Untill now Quant-PCR test always showed "Not Detected".
Test Name Results Units
-----------------------------------------------------------------------------------------------------------------
BCR-ABL Gene Rearrangement, PCR Quantitative
(Real Time PCR) Not Detected %
Report for last two tests over a period of an year is showing some extra information, (although numbers mentioned in last 2 reports are exactly same)
Test Name Results Units
-----------------------------------------------------------------------------------------------------------------
BCR-ABL Gene Rearrangement, PCR Quantitative
(Real Time PCR)
P210(e13fa2, e14a2, Major) BCR-ABL rearraged copy 0
P190(e1a2, minor) BCR ABL rearranged copy number 0
ABL copy number 10693
BCR-ABL percentange ratio <0.010 %
BCR-ABL international Scale Normalized copy number <0.006
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Reference table as mentioned in the report
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SIGNIFICANCE OF PERCENTAGE
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% RATIO REMARKS
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<0.01 COMPLETE MOLECULAR RESPONSE
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0.01-0.1 MAJOR MOLECULAR RESPONSE
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<1%-0.1 COMPLETE CYTOGENETICS RESPONSE
I am unable to comprehend the report, unfortunately her oncologist didn't give much information just that and i quote "her BCR is increased and we might need to change her medication".
I will be very thankful if someone can explain the change in last report, does this means she is entering into Accelerated Phase?
Thanks in advance
Karan