Searching for some information and as always really appreciate the knowledge and help from this group.
I have been dealing with a pleural effusion for three and a half years. Over this time I have had numerous thoracentesis performed at the hospital, pleural catheters implanted on both the right and left sides ( not at the same time ). I know the pleural effusion was caused by Sprycel. The oncologist was resistant to changing to another TKI and when he did agree he placed me on Gleevec. This resulted in a severe full body edema along with the pleural effusion and back on Sprycel . Dosage of Sprycel stated at 100 to- 80 - to 70 - 50 and finally to 20mg. I was undetectable for 18 months on 20 mg Sprycel, numbers went up on Gleevec.
Changed oncologists who recommended Tasigna October 2017. I immediately became undectable at 150 mg Tasigna. I drain daily at home and the fluid levels have decreased from 1000ml daily to between 300 and 500 ml daily. I had an appointment with a pulmonogist ( had pneumonia in Feb and double lung infection in May ) to see if anything else is brewing concerning my lungs. She recommended a Cardiac Thoracic review to see if I would benefit from a pleurodesis which would possibly allow me to remove the catheter.
The cardiac doctor stated that the procedure may not work, or be effective more than 50%. One doctor previously said that because the fluid build up is caused by Sprycel, they doubted that pleurodesis would work at all.
I do not have any problem using the catheter to drain at home as it much less invasive than thoracentesis and no x-rays are needed.
Question, because I had such a severe reaction to Gleevec, if at some point I have a pleurodesis performed, is it possible that fluid will accumulate in other areas instead of the pleural sac ? I've asked several doctors about this and no one seems to have an answer.