i first posted on here in 2015 after my dx of CML. I was started on sprycel and while my numbers went down well the side effects on bone pain muscle pain joint pain and headaches were unbearable. I switched oncologists. They changed me to gleevec. I did well felt great for about 6 weeks, two of which I wasn't taking meds then 4 weeks newly starting gleevec. Everything changed after that! The headaches came back, the sinus inflammation started. Eyes swell off and on when I get the headaches n sinus pressure. When these symptoms stopped I began getting HORRIFIC leg cramps. They woke me every night for months. They're not as bad recently, but now I have severe joint pain. Knees, elbows, wrists and hips. I'm exhausted ALL of the time and depressed even while taking antidepressants. I am still working by the grace of GOD. I don't want to stop working, but I miss so much time from work that I feel bad for my colleagues! If I change to another TKI will this happen again? I do walk and stretch. It helps minimally. I drink plenty of water. Can I get some feedback from others? Are you all working? How is your quality of life? I'm 58 and feel like 108!!