I am going to resurrect the discussion on this topic if I may because I am going to join you in that within the last few days following biopsies we now have to develop a treatment plan for prostate cancer.My Gleason score is similar to yours 3 +4 and this indicates that it might not be too aggressive and should be possible to treat it (apparently 4+3 is different and indicates it would be faster growing).Mine has not yet broken out into other organs or the lymph nodes so is more easily treatable.Early diagnosed prostate issues have a 90% chance of a cure;later more established ones are difficult to treat and of course over 11,000 men in UK die of this condition every year.
I have trawled the literature on co-malignancies and CML and whether the tkis and in particular imatinib (on it for 13 years with great success) causes prostate issues but there are no real definitive studies out there to back up a firm association.Various medics have in the past advised me to raise the bar higher and be more suspicious of any small indication of a secondary malignancy and this is why about two years ago I was advised to have regular PSA tests-as we know these are not always helpful but now with the use follow up multiparametric (with contrast using gadolinium) MRIs of the prostate are extremely helpful as a further real indicator of inflammation that might be malignant that might suggest a need for a biopsy.
I have been advised of 3 options from radical prosectomy which even under robot surgery is still quite an event with side effects;radiation beam therapy and 4D brachytherapy. So because one of the worlds centres of excellence for brachytherapy is very near to me and because it has a proven record we will go for that;having health insurance means that it will be done very soon.Brachytherapy involves the implantation of tiny iodine chips into the prostate to disseminate and dissolve targeted radiation to kill off cancerous cells-I will be radioactive for about 9 months! It involves a general anesthetic but only a one night hospital stay so it is a quick and a relatively non-invasive procedure.
Has anyone seen any studies of so called adjunct radiation therapies on CML patients with co malignancies and would this radiation and some follow CT scans be an additional risk for CML to return in a more aggressive form? I have seen some studies of breast cancer patients that were subjected to radiation therapy who went on to develop CML but only a small number of cases.
Are there any CML patients out there who have developed co malignancies with stories or advice or other CML patients with prostate cancer as well?
My conclusion is that if you are over 50 and male with CML be more suspicious of developing co-conditions and the PSA test might be somewhat useful as a starter because often prostate issues have no early symptoms.
I wish you well,