Hi All,
I’ve been on Glivec 400mg for the past 18 months after discovering intolerance to Tasigna during initial diagnosis of CML.
My BCR-ABL results went from 1.4% —> 0.4% and after another 6 months —> 0.3%.
By 18months I was supposed to achieve <0.1% at least. Based on this information, my doctor has offered two options:
1) continue another 6 months on Glivec 400mg and check again if PCR has further significant reduction (risk: PCR may go up)
2) increase dosage of glivec to 600mg.
what would be your recommendations based on experience here? Should I be very concerned?