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Emerging importance of vitamin K2

"Mylodysplastic syndromes (MDS) is a disorder related to leukemia, but unlike leukemia, MDS cells can be induced to develop into mature normal cells, and that is where vitamin K shows its role. Vitamin K treatment of bone marrow cells from patients with MDS strongly induces apoptosis of the diseased cells. Vitamin K2 also induces MDS cells to differentiate into healthy white blood cells, even when full-blown leukemia has developed. The combination of vitamin K2 and vitamin D3 achieved good differentiation in a laboratory study of leukemic cells, suggesting that it might be effective therapy for both MDS and leukemia. The oral dose for MDS is 45 to 90 mg of vitamin K2 analogue MK-4 daily.7"

I have been taking vitamin K2 for several years now - mostly for cardiovascular health (reduce calcium in arteries). K2 impact on leukemic cells is new information and makes sense when coupled with vitamin D's role in driving blast cell (leukemic & normal) differentiation. Ironic that vitamins D & K2 relates to bone health and the bone is where blood is made! Bone cells (osteoclasts) and blood cells are from the same cell lineage. Brilliant design. So bone health and blood/immune health go hand in hand.

So ... in addition to TKI drugs, patients should consider nutritional support to enhance our body's natural protection against leukemia. It might also help when the time comes to stop treatment and test remission.

I am becoming convinced that if I had known what I know now about vitamin D, K2, and other nutritional support (i.e. regular fasting), I would likely never have developed CML. This is important for our friends and family who are "healthy" and CML-free. They should consider adding D and K2 to their diet as a potential leukemia prevention program. No guarantee, but anything that could help is good.

I am newly diagnosed with chronic phase CML and was wondering about continuing to take vit K while on Sprycel.  Would you know if there are any contraindications?  Thanks!

I take sprycel and I take vitamin K2

(vitamin K2 is one of 3 "K" vitamins. they are not the same. Vitamin K1 (blood clotting), K2 (calcium chemistry), K3 () ).

So I'm wondering about the dosing of K2 in relation to this research.  The K2 I've been taking is MK-7 and it says each softgel contains 90 micrograms.

The article states: "The oral dose for MDS is 45 to 90 mg of vitamin K2 analogue MK-4 daily."

Is MK-4 less potent than MK-7, or does it just take a really high dose of K2 to have an effect on MDS?

MK-4 does not have as much therapeutic impact as MK-7 although it has some.

The article incorrectly lists "mg" instead of "mcg". Microgram is the correct unit of measure.

MK-7 has a longer half-life in the blood vs MK-4.

I take a minimum of 200 mcg vitamin K2 as MK-7 per day. My supplement also contains MK-4, but I ignore it as being the primary source of vitamin K2 for the purpose of heart, bone and blood health.



where do you get your K2 mk5 from please.

its been very useful reading your post, thank you! 👍🏻

Here is a resource list:

The one I take is from Innovix Labs (number 4 on the list).


Hey scuba  I recently had my vitamin d and k checked before taking supplements. My doctor mistakenly checked my vitamin k1 levels and they came out above normal. Does k2 effect my k1 levlels. Trying to find research if there’s harm in taking too much k2. 

No harm in taking too much K2 - although for practical and cost reasons, you don't want to go much above 800 mcg per day.

I take about 400 mcg per day between natto and supplements. I keep my K2 supplement level at 200 mcg per day.

vitamin K1 & K2 have a similar structure but perform different functions in the body.