I ditto Felix. Your doc will probably not go for 50 (even though there is evidence from a study to say starting with 50 dasatinib is fine), but you'd probably be OK for several months at 100. If you show a nice fast downward swoop, he'll be more amenable to reducing to 50 and you'll probably be able to avoid the pleural effusion. Yes, that 30% incidence is correct. The bothersome-ness of it varies wildly. Some people have very little fluid but a great deal of shortness of breath. Others can be alarmingly topped up, but with no symptoms. I've had 4 pleural effusions, and without giving the story of each one, I can tell you that I never knew I had it and they were discovered by accident. Each time they went almost completely away off dasatinib, but the problem was that my PCR zoomed back up pretty fast. This does not happen to everybody, however. Many people can wait it out, get rid of the effusion completely (this can take anywhere from 3 weeks to 6 months - maybe longer) and still not lose MMR. Be assured that you can regain your good PCR number after starting up dasatinib again - this has been proven again and again. Draining the fluid, similarly, can be a one-off walk in the park or a chronic ordeal - people have different experiences. I was able to reduce from 100 to 70 to 50, but still got the pleural effusion back. My enthusiasm for dasatinib was such a motivator, that I convinced my onc to try 20. That seemed to do the trick - I have remained with double zeros to the right for the whole time (about 2 years on 20 now) and have only minimal residual fluid that doesn't bother me or the pulmonologist. I see him once a year and get a chest x-ray. Here's a tip for if you do decide on dasatinib: anytime anybody listens to your lungs with a stethoscope, be sure to have them go much, much, much lower on your ribcage (down at your waist) to listen, because otherwise they'll miss a beginning effusion.